【文献精读】
掌握最原先学术动态
延展专业学问
来进行科学研究撰文撰写
欢 召 关口 唯 Luffy频道
食道超音波检验术前营养素饮料的食道排空:一项随机对照非劣效性研究者
BACKGROUND: Tools for the evaluation of gastric emptying(食道排空) he evolved over time. The purpose of this study was to show that the risk of pulmonary aspiration(肠胃误吸) is not increased with carbohydrate drink, by demonstrating that the gastric antral cross-sectional area (CSA)(食道窦梯形容) of the NO-NPO group is either equivalent to or less than that of the NPO (nil per os) group.
取材:检验食道排空的基本功能随着一段时间的推移而发展。本研究者的目地是通过断定NO-NPO分组的食道窦梯形容(CSA)也就是说或极小NPO分组，来断定营养素饮料没有减少肠胃误吸的不确定性。
METHODS: Sixty-four patients scheduled for elective laparoscopic(冠状动脉的)benign(良性的) gynecologic(主治医师外科的) surgery were enrolled and randomly assigned to the NPO group (n = 32) or the NO-NPO group (n = 32). After hing a regular meal until midnight before surgery, the NPO group fasted(常在)until surgery, while the NO-NPO group ingested 400 mL of a carbohydrate drink at midnight and freely up to 2 hours before anesthesia. The primary outcome was the gastric antral CSA by gastric ultrasound（肠胃部超音波) in right lateral decubitus position (RLDP)（直侧卧位). Noninferiority was defined as a mean difference of CSA 1.5ml/kg, and Perlas grade.
方法有:为了让64举例再议冠状动脉良性妇科切除患者，随机分为NPO分组(n = 32)和NO-NPO分组(n = 32)。NPO分组在术前正常喂食至晚间后常在至切除，而NO-NPO分组在晚间喂食400毫升营养素饮料，并在前2足足公民权利喂食。主要观察结果为直侧卧位(RLDP)食道超音波食道窦CSA。非劣效性定义为CSA 1.5 mL/kg和Perlas级。
所示1 食道窦部梯形容观测代备注所示
显示CSA在2个垂直方向上直径的观测
备注1 患者的弧特征
数据以平均值标准偏差、平均收入(四分位范围内)或十六进制(%)暗示
所示2 此研究者范举例
备注2 食道窦CSA, Perlas基准，食道体容，食道超音波检验危险食道致死率
数据以平均值标准偏差、平均收入(四分位范围内)或十六进制(%)暗示
所示3 NPO分组与NO-NPO分组直侧卧位食道窦部梯形容平均值差的非劣效所示
虚线暗示非劣效边界(Δ)。误差条暗示梯形面容关口联(NO-NPO分组−NPO分组)的95% CI。该所示描述了两分组彼此之间的非劣效性(等效性)
RESULTS: CSA in RLDP was not different between the NPO group (6.25 ± 3.79cm2) and the NO-NPO group (6.21 ± 2.48 cm2; P=.959). The mean difference of CSA in RLDP (NO-NPO group − NPO group) was 0.04 (95%l [CI],−1.56 to 1.64), which was within the noninferiority margin of 2.8 cm2. CSA was not different between the 2 groups (4.17 ± 2.34cm2 in NPO group versus 4.28 ± 1.23cm2 in NO-NPO group; P=.828). GV in NPO group (70 ± 56 mL) was not different from NO-NPO group (66 ± 36 mL; mean difference,3.66; 95%CI,−20 to 27; P=.756). GV/kg in the NPO group (1.25±1.00mL/kg) was not different from the NO-NPO group (1.17±0.67mL/kg;P=.694). The incidence of GV/kg> 1.5 mL/kg was not different between NPO (31.3%) and NO-NPO group (21.9%;P=.768). The median (interquartile range) of the Perlas grade was 1 (0–1) in NPO group and 0.5 (0–1) in NO-NPO group (P=.871).
结果:RLDP CSA在NPO分组(6.25±3.79cm2)和NO-NPO分组(6.21±2.48cm2)彼此之间无异质性关口联;P=.959)。RLDP (NO-NPO分组-NPO分组)CSA的平均值差为0.04, 95%[CI]:−1.56-1.64)，在2.8 cm2的非劣势以内。两分组间CSA无关口联(NPO分组为4.17±2.34 cm2, NO-NPO分组为4.28±1.23cm2;P=.828)。NPO分组GV(70±56 mL)与NO-NPO分组(66±36 mL)无显着关口联;平均值差,3.66;95% Cl:20-27,P=.756) NPO分组GV/kg(1.25±1.00mL/kg)与NO-NPO分组GV/kg(1.17±0.67 mL/kg)无显著关口联;P=.694)。Perlas基准的平均收入(四分位数范围内)在NPO分组为1 (0-1)，在NO-NPO分组为0.5 (0-1)(P=.871)。
CONCLUSIONS:Preoperative carbohydrates ingested up to 2 hours before anesthesia do not delay gastric emptying compared to midnight fasting(晚间常在), as evaluated with gastric ultrasound.
论证:根据食道超音波检验，与晚间常在相比，前2足足进食营养素没有延迟食道排空。
词汇备注：ASA =美国学家学会; BMI =肥胖指数;原先联盟=总合报告试验标准; ci =置信区间; CSA =梯形容; GV =食道体容; ICC =人体内相关口系数; IQS =清晰度最高分; IVC =下腔静脉; l =肝脏; LD =最多直径;每个OS的NPO = NIL; p =胰腺; RLDP =直侧褥疮位置; SD =最短直径; SMD =系统化平均值关口联; SPSS =社会科学的统计包被
学习笔记
1
外科用语
gastric 食道的
gastric emptying 食道排空
gastric volume 食道体容
gastric ultrasound assessing食道超音波检验
gastric antral 食道窦
cross-sectional area 梯形容
pulmonary 肠胃部的
pulmonary aspiration 肠胃误吸
laparoscope 冠状动脉
laparoscopic 冠状动脉的
gynecology 主治医师
gynecologic主治医师外科的
fast 常在
midnight fasting 晚间常在
ingest 摄取
right lateral decubitus position 直侧卧位
decubitus 褥疮；卧位
supine position 仰卧位
2
学问延展
非劣效性试验：一种随机对照临床试验（RCT）。在这种试验中，研究者者将一种原先的治疗法方法有与一种标准的有活性的药物（不是与安慰剂或不来进行治疗法的对照分组）来进行比较，借此属实原先治疗法方法有的不比对照药物差。当预期一种原先药与对比药有相似有效性但同时能缺少某些比对照药优越之处时，可以采用非劣效性试验。
相关新闻
相关问答
